AEROPERL® 300 Pharma – a versatile carrier for liquid or low-solubility APIs
AEROPERL® 300 Pharma is a granulated form of colloidal silicon dioxide.
Unlike highly disperse AEROSIL® products, AEROPERL® 300 Pharma consists of bead-like mesoporous granules with a particle size of on average 30 to 40 μm. The high specific surface area of 300 m2/g, coupled with the mesopore volume of approx. 1.6 ml/g means that AEROPERL® 300 Pharma is a versatile and highly absorptive carrier that may be used to incorporate liquids into solid pharmaceutical dosage forms.
Advantages of AEROPERL® 300 Pharma include:
High tapped density and nearly spherical shape: AEROPERL® 300 Pharma is easy to handle, even when loaded with more than its weight in liquid.
Hydrophilic nature: AEROPERL® 300 Pharma is an efficient desiccant. For example, AEROPERL® 300 Pharma may be used in cost efficient moisture assisted dry granulation (MADG) processes to assist in absorbing and distributing the small amount of water used.
High absorption capacity and high surface area: AEROPERL® 300 Pharma may help to avoid costly and time consuming API crystallization. AEROPERL® may also assist to increase the bioavailability of low-solubility APIs.
AEROPERL® 300 Pharma fulfils requirements of Ph. Eur. as well as USP/ NF. Due to its high bulk density, AEROPERL® 300 Pharma does not fulfill the “volume test” of the JP, however it complies with all other JP parameters.