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AEROSIL® colloidal silicon dioxide for semi-solid dosage forms

Pharmaceuticals

Industries

In suppositories AEROSIL® colloidal silicon dioxide may be used to thicken the suppository base to the desired viscosity, but even more importantly, it keeps the active ingredient evenly suspended until the product has cooled and set. In addition, it can improve the thermal stability of suppositories by increasing the softening temperature of the mass (e.g. during storage in warm climates) while not changing the melting temperature (e.g. during production).

The thickening and stabilizing properties of AEROSIL® colloidal silicon dioxide are also the reason it is used in formulating transdermal delivery systems.

AEROSIL product recommendations for semi-solid dosage forms

Effect

Benefits

Products

Dosage form: semi-solid (suppositories, transdermal patches)

Viscosity control

• Increase viscosity

• Inorganic thickener not metabolized by microbes

AEROSIL® 200 PharmaAEROSIL® 300 Pharma

Stabilization

• Keeps active ingredient uniformly distributed

AEROSIL® 200 PharmaAEROSIL® 300 PharmaAEROSIL® R 972 Pharma