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半固体状薬剤

応用分野

AEROSIL® COLLOIDAL SILICON DIOXIDE FOR SEMI-SOLID DOSAGE FORMS


AEROSIL_Pflaster
In suppositories AEROSIL®colloidal silicon dioxide may be used to thicken the suppository base to the desired viscosity, but even more importantly, it keeps the active ingredient evenly suspended until the product has cooled and set. In addition, it can improve the thermal stability of suppositories by increasing the softening temperature of the mass (e.g. during storage in warm climates) while not changing the melting temperature (e.g. during production).
The thickening and stabilizing properties of AEROSIL®colloidal silicon dioxide are also the reason it is used in formulating transdermal delivery systems
 
 
AEROSIL® product recommendations for semi-solid dosage forms
Effect
Benefits
Products
Dosage form: semi-solid (suppositories, transdermal patches)
Viscosity control
• Increase viscosity
• Inorganic thickener not metabolized by microbes
AEROSIL® 200 PharmaAEROSIL® 300 Pharma
Stabilization
• Keeps active ingredient uniformly distributed
AEROSIL® 200 PharmaAEROSIL® 300 PharmaAEROSIL® R 972 Pharma